The Journal of Biological Chemiitry

نویسندگان

  • M. M. Brysk
  • C. Ressler
چکیده

y-Cyano-cr-L-aminobutyric acid is identified for the first time as a biological substance. This amino acid nitrile accumulates when inorganic cyanide is administered to young cultures of Chromobacferium violaceum strain D 341. Cyanide supplies the cyano group, and aspartic acid supplies carbon atoms 1 to 4. Biosynthesis of P-cyanoalanine also takes place and appears to be controlled by aspartic acid. No evidence has been obtained for appreciable metabolism of y-cyano-cr-aminobutyric acid. Identification has been based on a close comparison of the physical and chemical properties of the isolated crystalline substance with known synthetic y-cyano-or-L-aminobutyric acid. The latter has been prepared by an improved procedure involving hydrogenolysis of the benzyloxycarbonyl derivative.

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تاریخ انتشار 2003